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HRID1744881

反应详情

EQUATION

反应方程式

HRID 1744881 的结构方程式

REACTANTS

反应物

3
结构：CCOC(=O)C[C@H]1CCCc2c1n([C@@H](C)c1ccc(Cl)cc1)c1c(S(C)(=O)=O)cc(F)cc21
HCID66967751

未命名化合物

结构：CCC(C(=O)[O-])C1CCCc2c1[nH]c1c(S(C)(=O)=O)cc(F)cc21
HCID86594996

未命名化合物

结构：CCOC(=O)C[C@@H]1CCCc2c1n([C@@H](C)c1ccc(Cl)cc1)c1c(S(C)(=O)=O)cc(F)cc21
HCID86615644

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@H](c1ccc(Cl)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O
HCID11259797

未命名化合物

PROCEDURE

实验过程

Alternatively (+/−) ethyl[6-fluoro-8-(methylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-1-yl]acetate was used for the alkylation reaction in step 5 to give a mixture of 2 diastereomers: ethyl[(1R)-9-[(1S)-1-(4-chlorophenyl)ethyl]-6-fluoro-8-(methylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-1-yl]acetate and ethyl[(1S)-9-[(1S)-1-(4-chlorophenyl)ethyl]-6-fluoro-8-(methylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-1-yl]acetate. The diastereomeric mixture was resolved by selective hydrolysis using the following procedure to give the desired [(1R)-9-[(1S)-1-(4-chlorophenyl)ethyl]-6-fluoro-8-(methylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-1-yl]acetic acid.

WORKUP

后处理

  1. customto give
  2. additiona mixture of 2 diastereomers
  3. customThe diastereomeric mixture was resolved by selective hydrolysis