(1R)-1-[4-(trifluoromethyl)phenyl]ethanol → HCID 58607116, compound

HRID 1744885Notes

Reaction equation

HRID 1744885 reaction equation
C[O:2][C:3](=[O:24])[CH2:4][C@@H:5]1[C:17]2[NH:16][C:15]3[C:10](=[CH:11][C:12]([F:22])=[CH:13][C:14]=3[S:18]([CH3:21])(=[O:20])=[O:19])[C:9]=2[C:8](=[O:23])[CH2:7][CH2:6]1.[F:25][C:26]([F:37])([F:36])[C:27]1[CH:32]=[CH:31][C:30]([C@H:33](O)[CH3:34])=[CH:29][CH:28]=1>>[F:22][C:12]1[CH:11]=[C:10]2[C:15](=[C:14]([S:18]([CH3:21])(=[O:19])=[O:20])[CH:13]=1)[N:16]([C@H:33]([C:30]1[CH:29]=[CH:28][C:27]([C:26]([F:25])([F:36])[F:37])=[CH:32][CH:31]=1)[CH3:34])[C:17]1[C@@H:5]([CH2:4][C:3]([OH:2])=[O:24])[CH2:6][CH2:7][C:8](=[O:23])[C:9]2=1

Participants

3

Reactant 2

HCID 2779042(1R)-1-[4-(trifluoromethyl)phenyl]ethanolHCID 131725392HCID 131725392, compound

Product 1

HCID 58607116HCID 58607116, compound

Procedure

The procedures described in Example 1 were followed using compound of Step 1 and (1R)-1-[4-(trifluoromethyl)phenyl]ethanol to provide the title compound following the hydrolysis of the corresponding methyl ester. MS (+APCI) m/z 511.9 (M)+

Sources & evidence

ORD record
ord-666a0057d6ec42b0bf459004120cf7cf
Source dataset
uspto-grants-2006_03
Patent number
US07019022B2

Reaction notes

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