Methyl iodide → HCID 16004951, compound

HRID 1744894Notes

Reaction equation

HRID 1744894 reaction equation
[CH2:1]([O:3][C:4](=[O:28])[CH2:5][N:6]([CH2:8][CH2:9][CH:10]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[O:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=1)[CH3:7])[CH3:2].[I:29][CH3:30]>C1C=CC=CC=1>[I-:29].[CH3:7][N+:6]([CH3:30])([CH2:5][C:4]([O:3][CH2:1][CH3:2])=[O:28])[CH2:8][CH2:9][CH:10]([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)[O:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]([F:19])([F:20])[F:21])=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 22225898HCID 22225898, compound

Product 1

HCID 16004951HCID 16004951, compoundYield 85.7%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A solution of 0.152 g (0.38 mmol) N-[3-phenyl-3-(4-trifluoromethylphenoxy)propyl]sarcosine ethyl ester (Compound A21) and 0.273 g (1.93 mmol) iodomethane in 2 ml benzene was heated under reflux for 2 hours and the solvent evaporated. The residue was washed three times with anhydrous diethyl ether and dried under vacuum to give 0.175 g (yield 85%) dimethyl(ethoxycarbonylmethyl)[3-phenyl-3-(4-trifluoromethylphenoxy)propyl]ammonium iodide (Compound A148) as a pale yellow hygroscopic powder.

Workup

  1. temperatureunder reflux for 2 hours
  2. customthe solvent evaporated
  3. washThe residue was washed three times with anhydrous diethyl ether
  4. customdried under vacuum

Sources & evidence

ORD record
ord-130e34959e394a96b2c90b825e0bea70
Source dataset
uspto-grants-2006_03
Patent number
US07019024B2

Reaction notes

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