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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1744895Generated: October 27, 2026

2-Chloro-4'-fluoropropiophenone → N-[3-(4-Fluorophenyl)-3-oxopropyl]pipecolic acid methyl ester

https://huagongshe.com/reaction/1744895

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-4'-fluoropropiophenoneHCID 67672—
ReactantMethyl pipecolinateHCID 3463753—
ProductN-[3-(4-Fluorophenyl)-3-oxopropyl]pipecolic acid methyl esterHCID 5368147692%

Reaction Steps

N-[3-(4-Fluorophenyl)-3-oxopropyl]pipecolic acid methyl ester was prepared in 92% yield by alkylation of methyl pipecolinate with 3-chloro-4′-fluoropropiophenone (Aldrich) as described in Example 20A (Step 1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07019024B2
Source datasetuspto-grants-2006_03
ORD IDord-e751c77486734db788bbca8af135965e
Source noteuspto-grants-2006_03