(Imidazo[2,1-b][1,3]benzothiazol-2-yl)methanol → Imidazo[2,1-b][1,3]benzothiazole-2-carbaldehyde

Participants

Reaction Steps

To a stirred solution of imidazo[2,1-b]-benzthiazole-2-methanol (2.04 g, 10 mmol) in methylene chloride (200 ml), activated MnO2 (15 g, excess) was added. The reaction mixture was stirred at room temperature for 24 h and filtered through a pad of celite. The reaction mixture was concentrated and the product was purified by silica gel column chromatography by eluting it with 75% ethyl acetate; hexane. Brown solid; Yield: 800 mg, 40%; M+H 203.

Provenance & Evidence