NSC697569 → HCID 11817172, compound

HRID 1744920Notes

Reaction equation

HRID 1744920 reaction equation
[CH3:1][O:2][C:3]1[CH:19]=[CH:18][C:6]2[N:7]3[CH:12]=[C:11]([C:13](OCC)=[O:14])[N:10]=[C:8]3[S:9][C:5]=2[CH:4]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[CH3:1][O:2][C:3]1[CH:19]=[CH:18][C:6]2[N:7]3[CH:12]=[C:11]([CH2:13][OH:14])[N:10]=[C:8]3[S:9][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 394240NSC697569HCID 21226445Aluminium lithium hydride

Product 1

HCID 11817172HCID 11817172, compoundYield 40%

Procedure

7-methoxy imidazo[2,1-b]-benzthiazole-2-methanol was prepared according to the procedure outlined in Example 1, (Step 2). Starting from ethyl 7-methoxyimidazo[2,1-b]-benzthiazole-2-carboxylate (12.5 g, 43.5 mmol) and LiAlH4 solution (43.5 ml, 0.5 M solution in THF), 4.0 g (40% yield) of the alcohol derivative was isolated as a brown solid. (M+H) 235.

Workup

  1. custom7-methoxy imidazo[2,1-b]-benzthiazole-2-methanol was prepared

Sources & evidence

ORD record
ord-96a86f224e9845fdadf3a8f18a79db0e
Source dataset
uspto-grants-2006_03
Patent number
US07018997B2

Reaction notes

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