2-Amino-6-methylbenzothiazole → HCID 638597, compound

HRID 1744928Notes

Reaction equation

[CH3:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([NH2:9])[S:8][C:4]=2[CH:3]=1.Br[CH2:13][C:14](=O)[C:15]([O:17][CH2:18][CH3:19])=[O:16]>>[CH3:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]3[CH:13]=[C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[N:9]=[C:7]3[S:8][C:4]=2[CH:3]=1

Participants

Reactant 2

HCID 173352-Amino-6-methylbenzothiazole

HCID 66144Ethyl bromopyruvate

Product 1

HCID 638597HCID 638597, compoundYield 57.6%

Procedure

Ethyl 7-methylimidazo[2,1-b]-benzthiazole-2-carboxylate was prepared according to the procedure as outlined in Example 1, (Step 1). Starting from 6-methyl-2-amino benzothiazole (3.2 g, 20 mmol) and ethyl bromopyruvate (4.0 g, 20.4 mmol), 3.0 g (57% Yield) of ethyl 7-methylimidazo[2,1-b]-benzthiazole-2-carboxylate was isolated as brown solid. (M+H) 261.

Workup

customEthyl 7-methylimidazo[2,1-b]-benzthiazole-2-carboxylate was prepared

Sources & evidence

ORD record: ord-7bc6f49363974a0cbd9d0ef00ed1308d
Source dataset: uspto-grants-2006_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07018997B2

Reaction notes

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