HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Cyanobenzoyl chloride → 4-[((2S,4EZ)-4-[(benzyloxy)imino]-2-{[4-(3,4-dichlorophenyl)-1-piperazinyl]-carbonyl}pyrrolidinyl)carbonyl]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Cyanobenzoyl chloride | HCID 80172 | — |
| Reactant | 1-(3,4-Dichlorophenyl)piperazine | HCID 93601 | — |
| Reactant | (2S,4EZ)-4[(benzyloxy)imino]-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid | HCID 131725420 | — |
| Product | 4-[((2S,4EZ)-4-[(benzyloxy)imino]-2-{[4-(3,4-dichlorophenyl)-1-piperazinyl]-carbonyl}pyrrolidinyl)carbonyl]benzonitrile | HCID 131725422 | — |
Reaction Steps
Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(benzyloxy)imino]-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 4cyanobenzoyl chloride, and 1-(3,4-dichlorophenyl)piperazine the title compound was obtained in 43% purity by LC/MS. MS(ESI+): m/z=576.6.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07018988B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-4e871dec8c2245fb8c6a64869ad722a8 |
| Source note | uspto-grants-2006_03 |