Cyclopropylamine → HCID 131725431, compound

HRID 1745044Notes

Reaction equation

HRID 1745044 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=2)[CH2:10][C@H:9]1[C:24]([OH:26])=O)=[O:7])(C)(C)C.[N:27]([CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])=C=O.[CH:35]1([NH2:38])[CH2:37][CH2:36]1>>[CH:35]1([NH:38][C:24]([C@@H:9]2[CH2:10][C:11](=[N:13][O:14][CH2:15][C:16]3[CH:17]=[CH:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=3)[CH2:12][N:8]2[C:6]([NH:27][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])=[O:7])=[O:26])[CH2:37][CH2:36]1

Participants

4

Reactant 3

HCID 69828CyclopropylamineHCID 206036Pentane, 1-isocyanato-HCID 58714542HCID 58714542, compound

Product 1

HCID 131725431HCID 131725431, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-{[(4-methoxybenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, 1-isocyanatopentane, and cyclopropylamine the title compound was obtained in 75% purity by LC/MS. MS(ESI+): m/z=417.2.

Sources & evidence

ORD record
ord-6627569280d14ec79405b9ca79464f62
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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