HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxyazetidine → (2S)-1-({1-[4-(dimethylamino)butanoyl]-4-methylene-2-pyrrolidinyl}carbonyl)-3-azetidinol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxyazetidine | HCID 1514290 | — |
| Reactant | 4-(Dimethylamino)butanoyl chloride | HCID 15087690 | — |
| Reactant | (2S)-1-((tert-butoxy)carbonyl)-4-methylidenepyrrolidine-2-carboxylic acid | HCID 21727417 | — |
| Product | (2S)-1-({1-[4-(dimethylamino)butanoyl]-4-methylene-2-pyrrolidinyl}carbonyl)-3-azetidinol | HCID 69252460 | — |
Reaction Steps
Following the general method as outlined in Example 22, starting from 1-(tert-butoxycarbonyl)-4-methyleneproline, 4-(dimethylamino)butanoyl chloride, and 3-azetidinol the title compound was obtained in 100% purity by LC/MS. MS(ESI+): m/z=296.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07018988B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-2f534aa0c72b4b3788b1f4c9ddc87b1a |
| Source note | uspto-grants-2006_03 |