2-(1H-pyrrol-1-yl)aniline → HCID 131725439, compound

HRID 1745058Notes

Reaction equation

HRID 1745058 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH2:15][CH3:16])[CH2:10][C@H:9]1[C:17]([OH:19])=O)=[O:7])(C)(C)C.[Cl:20][C:21]1[CH:26]=[C:25]([N:27]=C=O)[CH:24]=[C:23]([Cl:30])[CH:22]=1.[N:31]1([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=2[NH2:42])[CH:35]=[CH:34][CH:33]=[CH:32]1>>[Cl:20][C:21]1[CH:26]=[C:25]([NH:27][C:6]([N:8]2[CH2:12][C:11](=[N:13][O:14][CH2:15][CH3:16])[CH2:10][C@H:9]2[C:17]([NH:42][C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][C:36]=2[N:31]2[CH:35]=[CH:34][CH:33]=[CH:32]2)=[O:19])=[O:7])[CH:24]=[C:23]([Cl:30])[CH:22]=1

Participants

4

Reactant 3

HCID 801232-(1H-pyrrol-1-yl)anilineHCID 944603,5-Dichlorophenyl isocyanateHCID 58714540(2S,4EZ)-1-(tertbutoxycarbonyl)-4-(ethoxyirnino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725439HCID 131725439, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(ethoxyimino)-2-pyrrolidinecarboxylic acid, 1,3-dichloro-5-isocyanatobenzene, and 2-(1H-pyrrol-1-yl)phenylamine the title compound was obtained in 54% purity by LC/MS. MS(ESI+): m/z=500.6.

Sources & evidence

ORD record
ord-9a5e9553c120494f868fb0919f86defd
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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