2,1,3-Benzothiadiazol-4-amine → HCID 131725442, compound

HRID 1745061Notes

Reaction equation

HRID 1745061 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[C:19]1([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:24]=[CH:23][C:22](C(Cl)=O)=[CH:21][CH:20]=1.[N:34]1[S:35][N:36]=[C:37]2[C:42]([NH2:43])=[CH:41][CH:40]=[CH:39][C:38]=12>>[N:34]1[S:35][N:36]=[C:37]2[C:42]([NH:43][C:16]([C@@H:9]3[CH2:10][C:11](=[N:13][O:14][CH3:15])[CH2:12][N:8]3[C:6]([C:31]3[CH:30]=[CH:29][C:28]([C:19]4[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=4)=[CH:33][CH:32]=3)=[O:7])=[O:18])=[CH:41][CH:40]=[CH:39][C:38]=12

Participants

4

Reactant 3

HCID 698452,1,3-Benzothiadiazol-4-amineHCID 841514-Phenylbenzoyl chlorideHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725442HCID 131725442, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]-4-carbonyl chloride, and 2,1,3-benzothiadiazol-4-amine the title compound was obtained in 66% purity by LC/MS. MS(ESI+): m/z=472.4.

Sources & evidence

ORD record
ord-c76069fc9f714bc3a5b5b9af25c11985
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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