Veratrylamine → HCID 131725452, compound

HRID 1745075Notes

Reaction equation

HRID 1745075 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[C:19]1([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:24]=[CH:23][C:22](C(Cl)=O)=[CH:21][CH:20]=1.[CH3:34][O:35][C:36]1[CH:37]=[C:38]([CH:41]=[CH:42][C:43]=1[O:44][CH3:45])[CH2:39][NH2:40]>>[C:28]1([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:29]=[CH:30][C:31]([C:6]([N:8]2[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]2[C:16]([NH:40][CH2:39][C:38]2[CH:41]=[CH:42][C:43]([O:44][CH3:45])=[C:36]([O:35][CH3:34])[CH:37]=2)=[O:18])=[O:7])=[CH:32][CH:33]=1

Participants

4

Reactant 3

HCID 79832VeratrylamineHCID 841514-Phenylbenzoyl chlorideHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725452HCID 131725452, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]-4-carbonyl chloride, and 3,4-dimethoxybenzylamine the title compound was obtained in 58% purity by LC/MS. MS(ESI+): m/z=488.4.

Sources & evidence

ORD record
ord-839e53a390914275aa0e043449ff5335
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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