Veratrylamine → HCID 69248775, compound

HRID 1745093Notes

Reaction equation

HRID 1745093 reaction equation
C(O[C:6]([N:8]1[CH2:15][C:14](=[O:16])[CH2:13][C@H:9]1[C:10]([OH:12])=O)=[O:7])(C)(C)C.[Cl:17][C:18]1[CH:23]=[C:22]([N:24]=C=O)[CH:21]=[C:20]([Cl:27])[CH:19]=1.[CH3:28][O:29][C:30]1[CH:31]=[C:32]([CH:35]=[CH:36][C:37]=1[O:38][CH3:39])[CH2:33][NH2:34]>>[Cl:27][C:20]1[CH:21]=[C:22]([NH:24][C:6]([N:8]2[CH2:15][C:14](=[O:16])[CH2:13][C@H:9]2[C:10]([NH:34][CH2:33][C:32]2[CH:35]=[CH:36][C:37]([O:38][CH3:39])=[C:30]([O:29][CH3:28])[CH:31]=2)=[O:12])=[O:7])[CH:23]=[C:18]([Cl:17])[CH:19]=1

Participants

4

Reactant 3

HCID 79832VeratrylamineHCID 944603,5-Dichlorophenyl isocyanateHCID 11593804(2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid

Product 1

HCID 69248775HCID 69248775, compound

Procedure

Following the general method as outlined in Example 22, starting from 1-(tert-butoxycarbonyl)-4-oxoproline, 1,3-dichloro-5-isocyanatobenzene, and 3,4-dimethoxybenzylamine the title compound was obtained in 48% purity by LC/MS. MS(ESI+): m/z=466.6.

Sources & evidence

ORD record
ord-393739b6b612451697be6858e6497c6a
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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