Phenoxyacetyl chloride → HCID 69454749, compound

HRID 1745100Notes

Reaction equation

HRID 1745100 reaction equation
C(O[C:6]([N:8]1[CH2:15][C:14](=[O:16])[CH2:13][C@H:9]1[C:10]([OH:12])=O)=[O:7])(C)(C)C.[O:17]([CH2:24]C(Cl)=O)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[N:28]1([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=2[NH2:39])[CH:32]=[CH:31][CH:30]=[CH:29]1>>[O:16]=[C:14]1[CH2:15][N:8]([C:6](=[O:7])[CH2:24][O:17][C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[C@H:9]([C:10]([NH:39][C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=2[N:28]2[CH:32]=[CH:31][CH:30]=[CH:29]2)=[O:12])[CH2:13]1

Participants

4

Reactant 3

HCID 69703Phenoxyacetyl chlorideHCID 801232-(1H-pyrrol-1-yl)anilineHCID 11593804(2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid

Product 1

HCID 69454749HCID 69454749, compound

Procedure

Following the general method as outlined in Example 22, starting from 1-(tert-butoxycarbonyl)-4-oxoproline, phenoxyacetyl chloride, and 2-(1H-pyrrol-1-yl)phenylamine the title compound was obtained in 42% purity by LC/MS. MS(ESI+): m/z=404.2.

Sources & evidence

ORD record
ord-55e349fb7e98490dbe7b5fe57986424c
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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