Methyl vinyl ketone → HCID 69249950, compound

HRID 1745126Notes

Reaction equation

HRID 1745126 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[CH:13][C:14]#[N:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=O)(C)(C)C.[CH3:19][C:20](=[O:23])[CH:21]=C.[CH2:24]([N:26]1[C:38]2[CH:37]=[CH:36][C:35]([NH2:39])=[CH:34][C:33]=2[C:32]2[C:27]1=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH3:25]>>[C:14]([CH:13]=[C:11]1[CH2:12][N:8]([CH2:6][CH2:19][C:20](=[O:23])[CH3:21])[C@H:9]([C:16]([NH:39][C:35]2[CH:36]=[CH:37][C:38]3[N:26]([CH2:24][CH3:25])[C:27]4[C:32]([C:33]=3[CH:34]=2)=[CH:31][CH:30]=[CH:29][CH:28]=4)=[O:18])[CH2:10]1)#[N:15]

Participants

4

Reactant 3

HCID 6570Methyl vinyl ketoneHCID 85883-Amino-9-ethylcarbazoleHCID 69250314(2S,4EZ)-1-(tertbutoxycarbonyl)-4-(cyanomethylene)-2-pyrrolidinecarboxylic acid

Product 1

HCID 69249950HCID 69249950, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(cyanomethylene)-2-pyrrolidinecarboxylic acid, 3-buten-2-one, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 59% purity by LC/MS. MS(ESI+): m/z=415.2.

Sources & evidence

ORD record
ord-5b72a52020e24f8d8bd164f125a473f9
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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