3-Amino-9-ethylcarbazole → HCID 131725483, compound

HRID 1745134Notes

Reaction equation

HRID 1745134 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[CH:13][C:14]#[N:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[Cl:19][C:20]1[CH:25]=[C:24]([N:26]=C=O)[CH:23]=[C:22]([Cl:29])[CH:21]=1.[CH2:30]([N:32]1[C:44]2[CH:43]=[CH:42][C:41]([NH2:45])=[CH:40][C:39]=2[C:38]2[C:33]1=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH3:31]>>[C:14]([CH:13]=[C:11]1[CH2:12][N:8]([C:6]([NH:26][C:24]2[CH:25]=[C:20]([Cl:19])[CH:21]=[C:22]([Cl:29])[CH:23]=2)=[O:7])[C@H:9]([C:16]([NH:45][C:41]2[CH:42]=[CH:43][C:44]3[N:32]([CH2:30][CH3:31])[C:33]4[C:38]([C:39]=3[CH:40]=2)=[CH:37][CH:36]=[CH:35][CH:34]=4)=[O:18])[CH2:10]1)#[N:15]

Participants

4

Reactant 3

HCID 85883-Amino-9-ethylcarbazoleHCID 944603,5-Dichlorophenyl isocyanateHCID 69250314(2S,4EZ)-1-(tertbutoxycarbonyl)-4-(cyanomethylene)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725483HCID 131725483, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(cyanomethylene)-2-pyrrolidinecarboxylic acid, 1,3-dichloro-5-isocyanatobenzene, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 60% purity by LC/MS. MS(ESI+): m/z=532.8.

Sources & evidence

ORD record
ord-da984fcd9a2644d7b3ea1b7921fce510
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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