Phenyl isocyanate → HCID 69250471, compound

HRID 1745136Notes

Reaction equation

C(O[C:6]([N:8]1[CH2:15][C:14](=[CH2:16])[CH2:13][C@H:9]1[C:10]([OH:12])=O)=[O:7])(C)(C)C.[N:17]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=C=O.[CH2:26]([N:28]1[C:40]2[CH:39]=[CH:38][C:37]([NH2:41])=[CH:36][C:35]=2[C:34]2[C:29]1=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH3:27]>>[CH2:26]([N:28]1[C:40]2[CH:39]=[CH:38][C:37]([NH:41][C:10]([C@@H:9]3[CH2:13][C:14](=[CH2:16])[CH2:15][N:8]3[C:6]([NH:17][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:7])=[O:12])=[CH:36][C:35]=2[C:34]2[C:29]1=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH3:27]

Participants

Reactant 3

HCID 7672Phenyl isocyanate

HCID 85883-Amino-9-ethylcarbazole

HCID 21727417(2S)-1-((tert-butoxy)carbonyl)-4-methylidenepyrrolidine-2-carboxylic acid

Product 1

HCID 69250471HCID 69250471, compound

Procedure

Following the general method as outlined in Example 22, starting from 1-(tert-butoxycarbonyl)-4-methyleneproline, isocyanatobenzene, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 66% purity by LC/MS. MS(ESI+): m/z=439.2.

Sources & evidence

ORD record: ord-527f23be57344defb35db17795339250
Source dataset: uspto-grants-2006_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07018988B2

Reaction notes

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