Benzoyl chloride → HCID 131725490, compound

HRID 1745142Notes

Reaction equation

HRID 1745142 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=2)[CH2:10][C@H:9]1[C:24]([OH:26])=O)=[O:7])(C)(C)C.C(Cl)(=O)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.[N:36]1[S:37][N:38]=[C:39]2[C:44]([NH2:45])=[CH:43][CH:42]=[CH:41][C:40]=12>>[N:36]1[S:37][N:38]=[C:39]2[C:44]([NH:45][C:24]([C@@H:9]3[CH2:10][C:11](=[N:13][O:14][CH2:15][C:16]4[CH:17]=[CH:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=4)[CH2:12][N:8]3[C:6](=[O:7])[C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)=[O:26])=[CH:43][CH:42]=[CH:41][C:40]=12

Participants

4

Reactant 3

HCID 7412Benzoyl chlorideHCID 698452,1,3-Benzothiadiazol-4-amineHCID 58714542HCID 58714542, compound

Product 1

HCID 131725490HCID 131725490, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-{[(4-methoxybenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, benzoyl chloride, and 2,1,3-benzothiadiazol-4-amine the title compound was obtained in 61% purity by LC/MS. MS(ESI+): m/z=502.4.

Sources & evidence

ORD record
ord-8ece62858c9d4910991f527c63b5d9b0
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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