Benzoyl chloride → HCID 131725496, compound

HRID 1745148Notes

Reaction equation

HRID 1745148 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH2:15][CH3:16])[CH2:10][C@H:9]1[C:17]([OH:19])=O)=[O:7])(C)(C)C.C(Cl)(=O)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.[Cl:29][C:30]1[CH:31]=[C:32]([N:37]2[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]2)[CH:33]=[CH:34][C:35]=1[Cl:36]>>[CH2:15]([O:14][N:13]=[C:11]1[CH2:10][C@@H:9]([C:17]([N:40]2[CH2:39][CH2:38][N:37]([C:32]3[CH:33]=[CH:34][C:35]([Cl:36])=[C:30]([Cl:29])[CH:31]=3)[CH2:42][CH2:41]2)=[O:19])[N:8]([C:6](=[O:7])[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:12]1)[CH3:16]

Participants

4

Reactant 3

HCID 7412Benzoyl chlorideHCID 936011-(3,4-Dichlorophenyl)piperazineHCID 58714540(2S,4EZ)-1-(tertbutoxycarbonyl)-4-(ethoxyirnino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725496HCID 131725496, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(ethoxyimino)-2-pyrrolidinecarboxylic acid, benzoyl chloride, and 1-(3,4-dichlorophenyl)piperazine the title compound was obtained in 51% purity by LC/MS. MS(ESI+): m/z=489.6.

Sources & evidence

ORD record
ord-4119a36550174c78ac2e10e9471c917c
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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