Acetyl chloride → HCID 131725509, compound

HRID 1745161Notes

Reaction equation

HRID 1745161 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH2:15][CH3:16])[CH2:10][C@H:9]1[C:17]([OH:19])=O)=[O:7])(C)(C)C.[C:20](Cl)(=O)C.[CH2:24]([N:26]1[C:38]2[CH:37]=[CH:36][C:35]([NH2:39])=[CH:34][C:33]=2[C:32]2[C:27]1=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH3:25]>>[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH2:15][CH3:16])[CH2:10][C@H:9]1[C:17]([NH:39][C:35]1[CH:36]=[CH:37][C:38]2[N:26]([CH2:24][CH3:25])[C:27]3[C:32]([C:33]=2[CH:34]=1)=[CH:31][CH:30]=[CH:29][CH:28]=3)=[O:19])(=[O:7])[CH3:20]

Participants

4

Reactant 3

HCID 6367Acetyl chlorideHCID 85883-Amino-9-ethylcarbazoleHCID 58714540(2S,4EZ)-1-(tertbutoxycarbonyl)-4-(ethoxyirnino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725509HCID 131725509, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(ethoxyimino)-2-pyrrolidinecarboxylic acid, acetyl chloride, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 87% purity by LC/MS. MS(ESI+): m/z=407.2.

Sources & evidence

ORD record
ord-fcd115e0c5db45bea1cbc8d77b69e7c7
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

Loading…