(2-Thienylmethyl)amine → HCID 131725514, compound

HRID 1745166Notes

Reaction equation

HRID 1745166 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=2)[CH2:10][C@H:9]1[C:24]([OH:26])=O)=[O:7])(C)(C)C.[N:27]([CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])=C=O.[S:35]1[CH:39]=[CH:38][CH:37]=[C:36]1[CH2:40][NH2:41]>>[CH3:23][O:22][C:19]1[CH:18]=[CH:17][C:16]([CH2:15][O:14][N:13]=[C:11]2[CH2:12][N:8]([C:6]([NH:27][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])=[O:7])[C@H:9]([C:24]([NH:41][CH2:40][C:36]3[S:35][CH:39]=[CH:38][CH:37]=3)=[O:26])[CH2:10]2)=[CH:21][CH:20]=1

Participants

4

Reactant 3

HCID 34005(2-Thienylmethyl)amineHCID 206036Pentane, 1-isocyanato-HCID 58714542HCID 58714542, compound

Product 1

HCID 131725514HCID 131725514, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-{[(4-methoxybenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, 1-isocyanatopentane, and 2-thienylmethylamine the title compound was obtained in 86% purity by LC/MS. MS(ESI+): m/z=473.2.

Sources & evidence

ORD record
ord-247dbefcb18c429a964b1bf36af5128a
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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