HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylbenzylamine → (2S,4EZ)-N2-benzyl-4-benzylidene-N2-methyl-N1-(3-methylphenyl)-1,2-pyrrolidinedicarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylbenzylamine | HCID 7669 | — |
| Reactant | m-Tolyl isocyanate | HCID 69303 | — |
| Reactant | (2S,4EZ)-4benzylidene-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid | HCID 69250545 | — |
| Product | (2S,4EZ)-N2-benzyl-4-benzylidene-N2-methyl-N1-(3-methylphenyl)-1,2-pyrrolidinedicarboxamide | HCID 131725527 | — |
Reaction Steps
Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-benzylidene-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 1-isocyanato-3-methylbenzene, and N-benzyl-N-methylamine the title compound was obtained in 68% purity by LC/MS. MS(ESI+): m/z=440.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07018988B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-fdb4421df0ab4ca986123e9838e854d7 |
| Source note | uspto-grants-2006_03 |