HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Piperonylpiperazine → (3Ez,5s)-5-{[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]carbonyl}-1-[(2-oxo-6-pentyl-2h-pyran-3-yl)carbonyl]-3-pyrrolidinone o-(tert-butyl)oxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Piperonylpiperazine | HCID 94426 | — |
| Reactant | 2-oxo-6-pentyl-2H-pyran-3-carbonyl chloride | HCID 22223512 | — |
| Reactant | (2S,4EZ)-1-(tertbutoxycarbonyl)-4-(tert-butoxyimino)-2-pyrrolidinecarboxylic acid | HCID 131725425 | — |
| Product | (3Ez,5s)-5-{[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]carbonyl}-1-[(2-oxo-6-pentyl-2h-pyran-3-yl)carbonyl]-3-pyrrolidinone o-(tert-butyl)oxime | HCID 131725542 | — |
Reaction Steps
Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(tert-butoxyimino)-2-pyrrolidinecarboxylic acid, 2-oxo-6-pentyl-2H-pyran-3-carbonyl chloride, and 1-(1,3-benzodioxol-5-ylmethyl)piperazine the title compound was obtained in 59% purity by LC/MS. MS(ESI+): m/z=595.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07018988B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-68711916e3d741ebbce85e1723a5880c |
| Source note | uspto-grants-2006_03 |