3-Amino-9-ethylcarbazole → HCID 131725545, compound

HRID 1745201Notes

Reaction equation

HRID 1745201 reaction equation
[CH2:1]([O:4][N:5]=[C:6]1[CH2:10][N:9]([C:11]([O:13]C(C)(C)C)=O)[C@H:8]([C:18]([OH:20])=O)[CH2:7]1)[CH:2]=[CH2:3].[Cl:21][C:22]1[CH:32]=[CH:31][C:25]([O:26][CH2:27]C(Cl)=O)=[CH:24][CH:23]=1.[CH2:33]([N:35]1[C:47]2[CH:46]=[CH:45][C:44]([NH2:48])=[CH:43][C:42]=2[C:41]2[C:36]1=[CH:37][CH:38]=[CH:39][CH:40]=2)[CH3:34]>>[CH2:1]([O:4][N:5]=[C:6]1[CH2:10][N:9]([C:11](=[O:13])[CH2:27][O:26][C:25]2[CH:31]=[CH:32][C:22]([Cl:21])=[CH:23][CH:24]=2)[C@H:8]([C:18]([NH:48][C:44]2[CH:45]=[CH:46][C:47]3[N:35]([CH2:33][CH3:34])[C:36]4[C:41]([C:42]=3[CH:43]=2)=[CH:40][CH:39]=[CH:38][CH:37]=4)=[O:20])[CH2:7]1)[CH:2]=[CH2:3]

Participants

4

Reactant 3

HCID 85883-Amino-9-ethylcarbazoleHCID 77771p-Chlorophenoxyacetyl chlorideHCID 58714562(2S,4EZ)-4-[(allyloxy)imino)-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725545HCID 131725545, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(allyloxy)-imino]-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, (4-chlorophenoxy)acetyl chloride, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 78% purity by LC/MS. MS(ESI+): m/z=545.4.

Sources & evidence

ORD record
ord-70fb79eecaab4d9bb8bd1c134955022f
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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