6-Aminoquinoline → HCID 69250954, compound

HRID 1745221Notes

Reaction equation

HRID 1745221 reaction equation
C(O[C:6]([N:8]1[CH2:15][C:14](=[CH2:16])[CH2:13][C@H:9]1[C:10]([OH:12])=O)=[O:7])(C)(C)C.[Cl:17][C:18]1[CH:23]=[C:22]([N:24]=C=O)[CH:21]=[C:20]([Cl:27])[CH:19]=1.[N:28]1[C:37]2[C:32](=[CH:33][C:34]([NH2:38])=[CH:35][CH:36]=2)[CH:31]=[CH:30][CH:29]=1>>[Cl:17][C:18]1[CH:23]=[C:22]([NH:24][C:6]([N:8]2[CH2:15][C:14](=[CH2:16])[CH2:13][C@H:9]2[C:10]([NH:38][C:34]2[CH:33]=[C:32]3[C:37](=[CH:36][CH:35]=2)[N:28]=[CH:29][CH:30]=[CH:31]3)=[O:12])=[O:7])[CH:21]=[C:20]([Cl:27])[CH:19]=1

Participants

4

Reactant 3

HCID 113736-AminoquinolineHCID 944603,5-Dichlorophenyl isocyanateHCID 21727417(2S)-1-((tert-butoxy)carbonyl)-4-methylidenepyrrolidine-2-carboxylic acid

Product 1

HCID 69250954HCID 69250954, compound

Procedure

Following the general method as outlined in Example 22, starting from 1-(tert-butoxy-carbonyl)-4-methyleneproline, 1,3-dichloro-5-isocyanatobenzene, and 6-quinolinamine the title compound was obtained in 65% purity by LC/MS. MS(ESI+): m/z=441.0.

Sources & evidence

ORD record
ord-5dd7f07cc2cf476485139db8a2669d46
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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