Benzoyl chloride → HCID 131725563, compound

HRID 1745229Notes

Reaction equation

HRID 1745229 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[C:18]([Cl:23])[CH:17]=2)[CH2:10][C@H:9]1[C:24]([OH:26])=O)=[O:7])(C)(C)C.C(Cl)(=O)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.[NH:36]1[CH2:41][CH2:40][O:39][CH2:38][CH2:37]1>>[Cl:23][C:18]1[CH:17]=[C:16]([CH:21]=[CH:20][C:19]=1[Cl:22])[CH2:15][O:14][N:13]=[C:11]1[CH2:10][C@@H:9]([C:24]([N:36]2[CH2:41][CH2:40][O:39][CH2:38][CH2:37]2)=[O:26])[N:8]([C:6](=[O:7])[C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH2:12]1

Participants

4

Reactant 3

HCID 7412Benzoyl chlorideHCID 8083MorpholineHCID 131725417(2S,4EZ)-1-(tert-butoxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725563HCID 131725563, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, benzoyl chloride, and morpholine the title compound was obtained in 69% purity by LC/MS. MS(ESI+): m/z=476.2.

Sources & evidence

ORD record
ord-44e42bf2061447be9222df2616a05933
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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