Phenylethanolamine → HCID 131725574, compound

HRID 1745243Notes

Reaction equation

HRID 1745243 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[O:19]([C:26]1[CH:27]=[C:28]([CH:32]=[CH:33][CH:34]=1)C(O)=O)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[NH2:35][CH2:36][CH:37]([C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)[OH:38]>>[OH:38][CH:37]([C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)[CH2:36][NH:35][C:16]([C@@H:9]1[CH2:10][C:11](=[N:13][O:14][CH3:15])[CH2:12][N:8]1[C:6](=[O:7])[C:28]1[CH:32]=[CH:33][CH:34]=[C:26]([O:19][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:27]=1)=[O:18]

Participants

4

Reactant 3

HCID 1000PhenylethanolamineHCID 195393-Phenoxybenzoic acidHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725574HCID 131725574, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 3-phenoxybenzoic acid, and (1RS)-2-amino-1-phenylethanol, the title compound was obtained in 94% purity by HPLC. MS(ESI+): m/z=474.

Sources & evidence

ORD record
ord-6dce1a75e47d4e808c14b45c7656f8b6
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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