HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Phenylbenzoyl chloride → (2S,4EZ)-1-([1,1'-biphenyl]-4-ylcarbonyl)-N-[(1R,2R)-2-(hydroxymethyl)-cyclohexyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Phenylbenzoyl chloride | HCID 84151 | — |
| Reactant | trans-(2-Aminocyclohexyl)methanol | HCID 2724655 | — |
| Reactant | (2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid | HCID 58714586 | — |
| Product | (2S,4EZ)-1-([1,1'-biphenyl]-4-ylcarbonyl)-N-[(1R,2R)-2-(hydroxymethyl)-cyclohexyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide | HCID 131725579 | — |
Reaction Steps
Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]-4-carbonyl chloride, and [(1R,2R)-2-aminocyclohexyl]methanol, the title compound was obtained in 65% purity by HPLC. MS(ESI+): m/z=450.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07018988B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-72a512a44afd467180a5c3decfaa0b6b |
| Source note | uspto-grants-2006_03 |