HRID1745258

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1515244

4-Pyridin-3-yl-benzoic acid

C12H9NO2

HCID2735360

1-amino-3-(4-methoxyphenoxy)propan-2-ol

C10H15NO3

结构：CON=C1C[C@@H](C(=O)O)N(C(=O)OC(C)(C)C)C1

HCID58714586

(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

C11H18N2O5

PRODUCTS

生成物

结构：CON=C1C[C@@H](C(=O)NCC(O)COc2ccc(OC)cc2)N(C(=O)c2ccc(-c3cccnc3)cc2)C1

HCID131725588

未命名化合物

PROCEDURE

实验过程

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 4-(3-pyridinyl)benzoic acid, and (2RS)-1-amino-3-(4-methoxyphenoxy)-2-propanol, the title compound was obtained in 63% purity by HPLC. MS(ESI+): m/z=519.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-19902e7314e54abcb75d3a8c871bfc61
来源数据集: uspto-grants-2006_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07018988B2
来源说明: uspto-grants-2006_03

反应 SMILES

C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[N:19]1[CH:24]=[CH:23][CH:22]=[C:21]([C:25]2[CH:33]=[CH:32][C:28](C(O)=O)=[CH:27][CH:26]=2)[CH:20]=1.[NH2:34][CH2:35][CH:36]([OH:47])[CH2:37][O:38][C:39]1[CH:44]=[CH:43][C:42]([O:45][CH3:46])=[CH:41][CH:40]=1>>[OH:47][CH:36]([CH2:37][O:38][C:39]1[CH:44]=[CH:43][C:42]([O:45][CH3:46])=[CH:41][CH:40]=1)[CH2:35][NH:34][C:16]([C@@H:9]1[CH2:10][C:11](=[N:13][O:14][CH3:15])[CH2:12][N:8]1[C:6](=[O:7])[C:28]1[CH:27]=[CH:26][C:25]([C:21]2[CH:20]=[N:19][CH:24]=[CH:23][CH:22]=2)=[CH:33][CH:32]=1)=[O:18]