HRID1745259

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID74192

(1,1'-Biphenyl)-4-sulphonyl chloride

C12H9ClO2S

HCID2735360

1-amino-3-(4-methoxyphenoxy)propan-2-ol

C10H15NO3

结构：CON=C1C[C@@H](C(=O)O)N(C(=O)OC(C)(C)C)C1

HCID58714586

(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

C11H18N2O5

PRODUCTS

生成物

结构：CON=C1C[C@@H](C(=O)NCC(O)COc2ccc(OC)cc2)N(S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1

HCID131725589

未命名化合物

PROCEDURE

实验过程

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]-4-sulfonyl chloride, and (2RS)-1-amino-3-(4-methoxyphenoxy)-2-propanol, the title compound was obtained in 69% purity by HPLC. MS(ESI+): m/z=554.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f7bfce4c65c34b769670950fe9ff2540
来源数据集: uspto-grants-2006_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07018988B2
来源说明: uspto-grants-2006_03

反应 SMILES

C(OC([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=O)(C)(C)C.[C:19]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:24]=[CH:23][C:22]([S:25](Cl)(=[O:27])=[O:26])=[CH:21][CH:20]=1.[NH2:35][CH2:36][CH:37]([OH:48])[CH2:38][O:39][C:40]1[CH:45]=[CH:44][C:43]([O:46][CH3:47])=[CH:42][CH:41]=1>>[C:19]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:24]=[CH:23][C:22]([S:25]([N:8]2[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]2[C:16]([NH:35][CH2:36][CH:37]([OH:48])[CH2:38][O:39][C:40]2[CH:45]=[CH:44][C:43]([O:46][CH3:47])=[CH:42][CH:41]=2)=[O:18])(=[O:27])=[O:26])=[CH:21][CH:20]=1