4-(Pyridin-4-yl)benzoic acid → HCID 131725594, compound

HRID 1745264Notes

Reaction equation

HRID 1745264 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[N:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:33]=[CH:32][C:28](C(O)=O)=[CH:27][CH:26]=2)=[CH:21][CH:20]=1.[NH2:34][CH2:35][CH:36]([OH:49])[CH2:37][O:38][C:39]1[CH:44]=[CH:43][C:42]([NH:45][C:46](=[O:48])[CH3:47])=[CH:41][CH:40]=1>>[C:46]([NH:45][C:42]1[CH:43]=[CH:44][C:39]([O:38][CH2:37][CH:36]([OH:49])[CH2:35][NH:34][C:16]([C@@H:9]2[CH2:10][C:11](=[N:13][O:14][CH3:15])[CH2:12][N:8]2[C:6](=[O:7])[C:28]2[CH:27]=[CH:26][C:25]([C:22]3[CH:21]=[CH:20][N:19]=[CH:24][CH:23]=3)=[CH:33][CH:32]=2)=[O:18])=[CH:40][CH:41]=1)(=[O:48])[CH3:47]

Participants

4

Reactant 3

HCID 15208114-(Pyridin-4-yl)benzoic acidHCID 12504728HCID 12504728, compoundHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725594HCID 131725594, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 4-(4-pyridinyl)benzoic acid, and N-(4-{[(2RS)-3-amino-2-hydroxypropyl]oxy}phenyl) acetamide, the title compound was obtained in 62% purity by HPLC. MS(ESI+): m/z=546.

Sources & evidence

ORD record
ord-0c0bd3fceb7843c38f8aa93857d2f17e
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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