(1,1'-Biphenyl)-4-sulphonyl chloride → (2S,4EZ)-1-([1,1'-biphenyl]-4-ylsulfony)-N-[(2R)-2hydroxy-2-phenyl-ethyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide

Participants

Role	Name	HCID	Charge
Reactant	(1,1'-Biphenyl)-4-sulphonyl chloride	HCID 74192	—
Reactant	(R)-(-)-2-Amino-1-phenylethanol	HCID 6951165	—
Reactant	(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid	HCID 58714586	—
Product	(2S,4EZ)-1-([1,1'-biphenyl]-4-ylsulfony)-N-[(2R)-2hydroxy-2-phenyl-ethyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide	HCID 131725600	—

Reaction Steps

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]-4-sulfonyl chloride, and (1R)-2-amino-1-phenylethanol, the title compound was obtained in 87% purity by HPLC. MS(ESI+): m/z=494.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07018988B2
Source dataset	uspto-grants-2006_03
ORD ID	ord-2ea5eaf3b36b4f7f9dd5f16efa6b718e
Source note	uspto-grants-2006_03