(1,1'-Biphenyl)-4-sulphonyl chloride → HCID 131725614, compound

HRID 1745284Notes

Reaction equation

HRID 1745284 reaction equation
C(OC([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=O)(C)(C)C.[C:19]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:24]=[CH:23][C:22]([S:25](Cl)(=[O:27])=[O:26])=[CH:21][CH:20]=1.[C:35]1([NH:41][CH2:42][CH2:43][NH2:44])[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1>>[NH:41]([CH2:42][CH2:43][NH:44][C:16]([C@@H:9]1[CH2:10][C:11](=[N:13][O:14][CH3:15])[CH2:12][N:8]1[S:25]([C:22]1[CH:23]=[CH:24][C:19]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[CH:20][CH:21]=1)(=[O:27])=[O:26])=[O:18])[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1

Participants

4

Reactant 3

HCID 74192(1,1'-Biphenyl)-4-sulphonyl chlorideHCID 742701,2-Ethanediamine, N1-phenyl-HCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725614HCID 131725614, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]4-sulfonyl chloride, and N1-phenyl-1,2-ethanediamine, the title compound was obtained in 73% purity by HPLC. MS(ESI+): m/z=493.

Sources & evidence

ORD record
ord-97d9584ccf2642749e42e3122520413d
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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