beta-Alaninamide → HCID 131725616, compound

HRID 1745287Notes

Reaction equation

HRID 1745287 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[C:19]1([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:20](C(Cl)=O)=[CH:21][CH:22]=[CH:23][CH:24]=1.[NH2:34][CH2:35][CH2:36][C:37]([NH2:39])=[O:38]>>[NH2:39][C:37](=[O:38])[CH2:36][CH2:35][NH:34][C:16]([C@@H:9]1[CH2:10][C:11](=[N:13][O:14][CH3:15])[CH2:12][N:8]1[C:6]([C:31]1[CH:30]=[CH:29][C:28]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:33][CH:32]=1)=[O:7])=[O:18]

Participants

4

Reactant 3

HCID 192802beta-AlaninamideHCID 12563768[1,1'-Biphenyl]-2-carbonyl chlorideHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725616HCID 131725616, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]carbonyl chloride, and 3-aminopropanamide, the title compound was obtained in 71% purity by HPLC. MS(ESI+): m/z=409.

Sources & evidence

ORD record
ord-f48d8ed5ca784628981f50bc77714e64
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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