4-Phenylbenzoyl chloride → HCID 131725621, compound

HRID 1745292Notes

Reaction equation

HRID 1745292 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[C:19]1([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:24]=[CH:23][C:22](C(Cl)=O)=[CH:21][CH:20]=1.[NH2:34][C@@H:35]1[C@H:40]2[CH2:41][C@H:37]([CH:38]=[CH:39]2)[C@@H:36]1[C:42]([NH2:44])=[O:43]>>[NH2:44][C:42]([C@H:36]1[C@@H:37]2[CH2:41][C@@H:40]([CH:39]=[CH:38]2)[C@H:35]1[NH:34][C:16]([C@@H:9]1[CH2:10][C:11](=[N:13][O:14][CH3:15])[CH2:12][N:8]1[C:6]([C:31]1[CH:30]=[CH:29][C:28]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)=[CH:33][CH:32]=1)=[O:7])=[O:18])=[O:43]

Participants

4

Reactant 3

HCID 841514-Phenylbenzoyl chlorideHCID 6553904HCID 6553904, compoundHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725621HCID 131725621, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]4-carbonyl chloride, and (1R,2S,3R,4S)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide, the title compound was obtained in 68% purity by HPLC. MS(ESI+): m/z=473.

Sources & evidence

ORD record
ord-aa801234de914345b03dc2cfe3cf5cd0
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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