4-Phenylbenzoyl chloride → (2S,4EZ)-1-([1,1'-biphenyl]-4-ylcarbonyl)-N-[(2S)-2-hydroxy-2-phenyl-ethyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide

Participants

Role	Name	HCID	Charge
Reactant	4-Phenylbenzoyl chloride	HCID 84151	—
Reactant	(1S)-2-amino-1-phenylethan-1-ol	HCID 643217	—
Reactant	(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid	HCID 58714586	—
Product	(2S,4EZ)-1-([1,1'-biphenyl]-4-ylcarbonyl)-N-[(2S)-2-hydroxy-2-phenyl-ethyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide	HCID 131725623	—

Reaction Steps

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]-4-carbonyl chloride, and (1S)-2-amino-1-phenylethanol, the title compound was obtained in 87% purity by HPLC. MS(ESI+): m/z=458.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07018988B2
Source dataset	uspto-grants-2006_03
ORD ID	ord-9477a70bce864c5a8b0582dbc80254d3
Source note	uspto-grants-2006_03