HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylethanolamine → (2S,4EZ)-1-[(3',4'-dichioro[1,1'-biphenyl]-4-yl)carbonyl]-N-[(2RS)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylethanolamine | HCID 1000 | — |
| Reactant | 4-(3,4-Dichlorophenyl)benzoic acid | HCID 2758156 | — |
| Reactant | (2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid | HCID 58714586 | — |
| Product | (2S,4EZ)-1-[(3',4'-dichioro[1,1'-biphenyl]-4-yl)carbonyl]-N-[(2RS)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide | HCID 131725642 | — |
Reaction Steps
Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 3′,4′-dichloro[1,1-biphenyl]-4-carboxylic acid, and (1RS)-2-amino-1-phenylethanol, the title compound was obtained in 89% purity by HPLC. MS(ESI+): m/z=527.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07018988B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-8e4e80b7e99c4cdbad16e0ccc16aa11f |
| Source note | uspto-grants-2006_03 |