(1S,2R)-2-Amino-1,2-diphenylethanol → HCID 131725658, compound

HRID 1745330Notes

Reaction equation

HRID 1745330 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[CH3:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[C:26]1[CH:31]=[CH:30][C:29](C(O)=O)=[C:28]([CH3:35])[CH:27]=1.[NH2:36][C@H:37]([C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1)[C@H:38]([C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[OH:39]>>[CH3:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[C:26]1[CH:31]=[CH:30][C:29]([C:6]([N:8]2[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]2[C:16]([NH:36][C@H:37]([C:46]2[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=2)[C@@H:38]([OH:39])[C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)=[O:18])=[O:7])=[C:28]([CH3:35])[CH:27]=1

Participants

4

Reactant 3

HCID 719822(1S,2R)-2-Amino-1,2-diphenylethanolHCID 219372462',3-Dimethyl[1,1'-biphenyl]-4-carboxylic acidHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725658HCID 131725658, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2′,3-dimethyl[1,1-biphenyl]-4carboxylic acid, and (1S,2R)-2-amino-1,2-diphenylethanol, the title compound was obtained in 73% purity by HPLC. MS(ESI+): m/z=562.

Sources & evidence

ORD record
ord-d1881c0f7fcc4de4a7b5fef0ddc70105
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

Loading…