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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1745337Generated: October 30, 2026

1-(3-(Trifluoromethyl)phenyl)piperazine → HCID 131725665, compound

https://huagongshe.com/reaction/1745337

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(3-(Trifluoromethyl)phenyl)piperazineHCID 4296—
Reactant2'-Methyl-biphenyl-4-carboxylic acidHCID 2759815—
Reactant(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acidHCID 58714586—
ProductHCID 131725665HCID 131725665—

Reaction Steps

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2′-methyl[1,1′-biphenyl]-4-carboxylic acid, and 1-[3-(trifluoromethyl)phenyl]piperazine, the title compound was obtained in 88% purity by HPLC. MS(ESI+): m/z=565.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07018988B2
Source datasetuspto-grants-2006_03
ORD IDord-71feabdc7b4c43e68128bab631d39917
Source noteuspto-grants-2006_03