Dimethylamine → HCID 131725668, compound

HRID 1745340Notes

Reaction equation

HRID 1745340 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[CH3:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[C:26]1[CH:31]=[CH:30][C:29](C(O)=O)=[CH:28][CH:27]=1.[CH3:35][NH:36][CH3:37]>>[CH3:15][O:14][N:13]=[C:11]1[CH2:12][N:8]([C:6]([C:29]2[CH:30]=[CH:31][C:26]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=3[CH3:19])=[CH:27][CH:28]=2)=[O:7])[C@H:9]([C:16]([N:36]([CH3:37])[CH3:35])=[O:18])[CH2:10]1

Participants

4

Reactant 3

HCID 674DimethylamineHCID 27598152'-Methyl-biphenyl-4-carboxylic acidHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725668HCID 131725668, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2′-methyl[1,1′-biphenyl]-4-carboxylic acid, and dimethylamine (5.6M in ethanol), the title compound was obtained in 94% purity by HPLC. MS(ESI+): m/z=380.

Sources & evidence

ORD record
ord-ccf47f4862634cada05576b81b0c51bb
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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