4-Phenylbenzoyl chloride → (2S,4EZ)-1-([1,1'-biphenyl]-4-ylcarbonyl)-N-[(3R)-3-hydroxy-3-phenyl-propyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide

Participants

Role	Name	HCID	Charge
Reactant	4-Phenylbenzoyl chloride	HCID 84151	—
Reactant	(R)-3-Amino-1-phenyl-propan-1-ol	HCID 11182697	—
Reactant	(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid	HCID 58714586	—
Product	(2S,4EZ)-1-([1,1'-biphenyl]-4-ylcarbonyl)-N-[(3R)-3-hydroxy-3-phenyl-propyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide	HCID 131725669	—

Reaction Steps

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]4carbonyl chloride, and (1R)-3-amino-1-phenyl-1-propanol, the title compound was obtained in 94% purity by HPLC. MS(ESI+): m/z=472.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07018988B2
Source dataset	uspto-grants-2006_03
ORD ID	ord-91af094a23df47f9a6fa3b8465f40923
Source note	uspto-grants-2006_03