4-Chlorobenzaldehyde → HCID 21019793, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of L-methionine methyl ester hydrochloride (2 g, 10.0 mmol) and sodium carbonate (1.06 g, 10.0 mmol) in water (46 mL) was added p-chlorobenzaldehyde (1.4 g, 10.0 mmol). The resulting mixture was stirred at 40° C. for 45 minutes then 17 h at room temperature. The white cloudy solution was extracted with dichloromethane (3×50 mL). The organic phase was washed with water (2×50 mL), dried over anhydrous magnesium sulfate and concentrated in vacuo to yield the title compound 2.6 g (91%) which was used in next step with out further purification.

Provenance & Evidence