tert-Butyl (4-(furan-3-yl)-2-nitrophenyl)carbamate → (2-Amino-4-furan-3-yl-phenyl)-carbamic acid tert.-butyl ester

HRID 1745491Notes

Reaction equation

HRID 1745491 reaction equation
[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:18]=[CH:17][O:16][CH:15]=2)=[CH:10][C:9]=1[N+:19]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Ni]>[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:18]=[CH:17][O:16][CH:15]=2)=[CH:10][C:9]=1[NH2:19])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 69592767tert-Butyl (4-(furan-3-yl)-2-nitrophenyl)carbamate

Product 1

HCID 69592861(2-Amino-4-furan-3-yl-phenyl)-carbamic acid tert.-butyl ester

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

Prepared from (4-furan-3-yl-2-nitrophenyl)-carbamic acid tert.-butyl ester (Example B6) by catalytic hydrogenation with Raney-Ni according to the general procedure G (method a). Obtained as a light brown solid. (744 mg).

Workup

  1. customObtained as a light brown solid

Sources & evidence

ORD record
ord-13e1a5c6b6e2491996a9e270b802322e
Source dataset
uspto-grants-2006_03
Patent number
US07018998B2

Reaction notes

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