tert-Butyl 2-nitro-4-(thiophen-2-yl)phenylcarbamate → tert-Butyl (2-amino-4-(thiophen-2-yl)phenyl)carbamate

HRID 1745498Notes

Reaction equation

HRID 1745498 reaction equation
[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[S:15][CH:16]=[CH:17][CH:18]=2)=[CH:10][C:9]=1[N+:19]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[S:15][CH:16]=[CH:17][CH:18]=2)=[CH:10][C:9]=1[NH2:19])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 59736984tert-Butyl 2-nitro-4-(thiophen-2-yl)phenylcarbamate

Product 1

HCID 57717474tert-Butyl (2-amino-4-(thiophen-2-yl)phenyl)carbamate

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Prepared from (2-nitro-4-thiophen-2-yl-phenyl)-carbamic acid tert.-butyl ester (Example C3) by catalytic hydrogenation with Pd/C according to the general procedure G (method a). Obtained as a beige powder (151 mg).

Sources & evidence

ORD record
ord-97587aeacb694cd7b1ba5741b8a5981d
Source dataset
uspto-grants-2006_03
Patent number
US07018998B2

Reaction notes

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