HCID 69592779, compound → tert-Butyl (3-amino-2'-fluoro-[1,1'-biphenyl]-4-yl)carbamate

HRID 1745516Notes

Reaction equation

HRID 1745516 reaction equation
[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])=[CH:10][C:9]=1[N+:21]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])=[CH:10][C:9]=1[NH2:21])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 69592779HCID 69592779, compound

Product 1

HCID 67361423tert-Butyl (3-amino-2'-fluoro-[1,1'-biphenyl]-4-yl)carbamate

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Prepared from (2′-fluoro-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example B10) by catalytic hydrogenation with Pd/C according to the general procedure G (method a). Obtained as a yellow solid (1.31 g).

Sources & evidence

ORD record
ord-a83473e6d26348008067ce98977140fd
Source dataset
uspto-grants-2006_03
Patent number
US07018998B2

Reaction notes

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