HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(2-methoxymethylsulfanyl-imidazol-1-yl)-benzoate → 3-[3-(2-Methoxymethylsulfanyl-imidazol-1-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(2-methoxymethylsulfanyl-imidazol-1-yl)-benzoate | HCID 22224921 | — |
| Reactant | Lithium Tert-butyl Acetate | HCID 86586795 | — |
| Product | 3-[3-(2-Methoxymethylsulfanyl-imidazol-1-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester | HCID 69592835 | — |
Reaction Steps
Prepared from ethyl 3-(2-methoxymethylsulfanyl-imidazol-1-yl)-benzoate [prepared by esterification of 3-(2-methoxymethylsulfanyl-imidazol-1-yl)-benzoic acid [CAS-No. 108035-46-7] with conc. H2SO4 in EtOH, followed by treatment with chloromethylmethyl ether and NaH in THF/DMF] by treatment with lithium tert.-butyl acetate according to general procedure H (method b). Obtained as an orange oil (1.82 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07018998B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-b6edd5a6348d439eb5db790e3c5af95e |
| Source note | uspto-grants-2006_03 |