HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(1H-tetrazol-1-yl)benzoic acid → 3-Oxo-3-(3-tetrazol-1-yl-phenyl)-propionic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(1H-tetrazol-1-yl)benzoic acid | HCID 750220 | — |
| Reactant | Potassium ethyl malonate | HCID 3446434 | — |
| Reactant | Magnesium Chloride | HCID 5360315 | — |
| Reactant | ethyl chloroformate Et3N | HCID 19692316 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 3-Oxo-3-(3-tetrazol-1-yl-phenyl)-propionic acid ethyl ester | HCID 69592791 | — |
Reaction Steps
Prepared from 3-tetrazol-1-yl-benzoic acid [CAS-No. 204196-80-5] by activation with ethyl chloroformate/Et3N and reaction with ethyl malonate potassium salt with Et3N and MgCl2 in CH3CN according to general procedure H (method a). Obtained as a light yellow solid (211 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07018998B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-d46172731fdb4a8fa19f8dd985f9cbf0 |
| Source note | uspto-grants-2006_03 |