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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1745544Generated: October 28, 2026

Ethyl 2-imidazol-1-yl-thiazole-4-carboxylate → 3-(2-Imidazol-1-yl-thiazol-4-yl)-3-oxo-propionic acid tert.-butyl ester

https://huagongshe.com/reaction/1745544

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 2-imidazol-1-yl-thiazole-4-carboxylateHCID 22224610—
ReactantLithium Tert-butyl AcetateHCID 86586795—
Product3-(2-Imidazol-1-yl-thiazol-4-yl)-3-oxo-propionic acid tert.-butyl esterHCID 69592768—

Reaction Steps

Prepared from ethyl 2-imidazol-1-yl-thiazole-4-carboxylate [CAS-No. 256420-32-3] by treatment with lithium tert.-butyl acetate according to general procedure H (method b). Obtained as an orange oil (12.0 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07018998B2
Source datasetuspto-grants-2006_03
ORD IDord-422347eab7e64b2f84c8e111a3eca5aa
Source noteuspto-grants-2006_03