HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → Benzenepropanoic acid, beta-oxo-3-(trifluoromethoxy)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Isopropenyl acetate | HCID 7916 | — |
| Reactant | Lithium Bromide | HCID 82050 | — |
| Reactant | Bis(trimethylsilyl) malonate | HCID 87656 | — |
| Reactant | 3-(Trifluoromethoxy)benzoyl chloride | HCID 522854 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | Benzenepropanoic acid, beta-oxo-3-(trifluoromethoxy)- | HCID 22224559 | — |
| Product | 2,2-Dimethyl-6-(3-trifluoromethoxy-phenyl)-[1,3]dioxin-4-one | HCID 22224728 | — |
Reaction Steps
The 3-oxo-3-(3-trifluoromethoxy-phenyl)-propionic acid was prepared from 3-trifluoromethoxybenzoyl chloride and bis(trimethylsilyl) malonate with Et3N and LiBr in CH3CN at 0° C. according to general procedure H (method c1). The crude material was transformed into the title compound by stirring in isopropenyl acetate and conc. H2SO4 according to general procedure J (method a). Obtained as an orange solid (2.27 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07018998B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-5e981e074a0440eab3a82ad00f743c2a |
| Source note | uspto-grants-2006_03 |